Article
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.
Cancer research - 1 Oct 2007
Schmidt Marjanka K, Reincke Scarlett, Broeks Annegien, Braaf Linde M, Hogervorst Frans B L, Tollenaar Rob A E M, Johnson Nichola, Fletcher Olivia, Peto Julian, Tommiska Johanna, Blomqvist Carl, Nevanlinna Heli A, Healey Catherine S, Dunning Alison M, Pharoah Paul D P, Easton Douglas F, Dörk Thilo, Van't Veer Laura J
Abstract excerpt
Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility. Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk. Data from molecular studies suggest a functional interaction between these genes. We therefore investigated the effect of TP53 R72P...
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