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MDM2 SNP309 and cancer risk: a combined analysis.

Carcinogenesis - 1 Nov 2007

Wilkening Stefan, Bermejo Justo Lorenzo, Hemminki Kari

Abstract excerpt

A paper by Bond et al. reported that a single-nucleotide polymorphism (SNP) in the intronic promoter region of the mouse double minute 2 (MDM2) gene (called SNP309) can significantly change the expression of MDM2 and thereby suppress the p53 pathway. Furthermore, it was shown that SNP309 accelerates tumor formation in Li-Fraumeni patients. This initial report aroused the attention of many researchers, which...

Topics

Breast Neoplasms
Colorectal Neoplasms
Gene Frequency
Humans
Lung Neoplasms
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2
Risk Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17827408
DOI: 10.1093/carcin/bgm191

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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MDM2 SNP309 and cancer risk: a combined analysis.PMID 17827408Read ↗

MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis.Semantic proximity Read ↗

An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

Association of MDM2 SNP309 variation with lung cancer risk: evidence from 7196 cases and 8456 controls.Semantic proximity Read ↗

MDM2 SNP309 polymorphism is associated with colorectal cancer risk.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis.Semantic proximity Read ↗

The MDM2 T309G polymorphism and risk of lung cancer: an updated meta-analysis of 10,186 cases and 14,155 controls.Semantic proximity Read ↗

Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk.Semantic proximity Read ↗

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