Article
High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation.
Circulation. Cardiovascular genetics - 1 Aug 2012
Olesen Morten S, Yuan Lei, Liang Bo, Holst Anders G, Nielsen Nikolaj, Nielsen Jonas B, Hedley Paula L, Christiansen Michael, Olesen Søren-Peter, Haunsø Stig, Schmitt Nicole, Jespersen Thomas, Svendsen Jesper H
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, Na(V)1.5, plays a pivotal role in setting the conduction velocity and the initial depolarization of the cardiac myocytes. We hypothesized that early-onset lone AF was associated with genetic variation in SCN5A. METHODS AND RESULTS: The coding sequence of SCN5A was sequenced in 192 patients with early-onset lone...
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