Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common polymorphism in SCN5A is associated with lone atrial fibrillation.

Clinical pharmacology and therapeutics - 1 Jan 2007

Chen L Y, Ballew J D, Herron K J, Rodeheffer R J, Olson T M

Abstract excerpt

The cardiac sodium channel (SCN5A) is a target for the treatment of arrhythmias. We hypothesized that vulnerability to atrial fibrillation (AF) could be caused by genetic variation in SCN5A. We recruited 157 patients with early-onset AF who lacked traditional risk factors, and 314 matched controls. SCN5A was subject to targeted genotyping of a common loss-of-function H558R polymorphism and comprehensive mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation
Share to Cardiac electrophysiology and arrhythmias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Genotype

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Polymorphism, Genetic

Share to Sodium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 17185997
DOI: 10.1038/sj.clpt.6100016
PMCID: PMC1933493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common polymorphism in SCN5A is associated with lone atrial fibrillation.PMID 17185997Read ↗

Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation.Semantic proximity Read ↗

Polymorphism H558R in the human cardiac sodium channel SCN5A gene is associated with atrial fibrillation.Semantic proximity Read ↗

High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation.Semantic proximity Read ↗

Common and rare variants in SCN10A modulate the risk of atrial fibrillation.Semantic proximity Read ↗

Prevalence and spectrum of GJA5 mutations associated with lone atrial fibrillation.Semantic proximity Read ↗

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation.Semantic proximity Read ↗

Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously associated with atrial fibrillation.Semantic proximity Read ↗

Significant association of rare variant p.Gly8Ser in cardiac sodium channel β4‐subunit SCN4B with atrial fibrillationSemantic proximity Read ↗

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.Semantic proximity Read ↗

Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.Semantic proximity Read ↗

Genetic aspects of lone atrial fibrillation: what do we know?Semantic proximity Read ↗

Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.