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Article

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation.

BMC medical genetics - 3 Apr 2012

Olesen Morten S, Bentzen Bo H, Nielsen Jonas B, Steffensen Annette B, David Jens-Peter, Jabbari Javad, Jensen Henrik K, Haunsø Stig, Svendsen Jesper H, Schmitt Nicole

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia. The potassium current IKs is essential for cardiac repolarization. Gain-of-function mutations in KV7.1, the pore-forming α-subunit of the IKs channel, have been associated with AF. We hypothesized that early-onset lone AF is associated with mutations in the IKs channel regulatory subunit KCNE1. METHODS: In 209 unrelated early-onset lone AF...

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Identifiers

PMID: 22471742
DOI: 10.1186/1471-2350-13-24
PMCID: PMC3359244

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