Article
Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction.
Circulation. Genomic and precision medicine - 1 May 2018
Macri Vincenzo, Brody Jennifer A, Arking Dan E, Hucker William J, Yin Xiaoyan, Lin Honghuang, Mills Robert W, Sinner Moritz F, Lubitz Steven A, Liu Ching-Ti, Morrison Alanna C, Alonso Alvaro, Li Ning, Fedorov Vadim V, Janssen Paul M, Bis Joshua C, Heckbert Susan R, Dolmatova Elena V, Lumley Thomas, Sitlani Colleen M, Cupples L Adrienne, Pulit Sara L, Newton-Cheh Christopher, Barnard John, Smith Jonathan D, Van Wagoner David R, Chung Mina K, Vlahakes Gus J, O'Donnell Christopher J, Rotter Jerome I, Margulies Kenneth B, Morley Michael P, Cappola Thomas P, Benjamin Emelia J, Muzny Donna, Gibbs Richard A, Jackson Rebecca D, Magnani Jared W, Herndon Caroline N, Rich Stephen S, Psaty Bruce M, Milan David J, Boerwinkle Eric, Mohler Peter J, Sotoodehnia Nona, Ellinor Patrick T
Abstract excerpt
BACKGROUND: Genetic variants at the SCN5A/SCN10A locus are strongly associated with electrocardiographic PR and QRS intervals. While SCN5A is the canonical cardiac sodium channel gene, the role of SCN10A in cardiac conduction is less well characterized. METHODS: We sequenced the SCN10A locus in 3699 European-ancestry individuals to identify variants associated with cardiac conduction, and replicated our findings...
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