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Article

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation.

Cardiovascular research - 1 Jun 2013

Olesen Morten Salling, Refsgaard Lena, Holst Anders Gaarsdal, Larsen Anders Peter, Grubb Søren, Haunsø Stig, Svendsen Jesper Hastrup, Olesen Søren-Peter, Schmitt Nicole, Calloe Kirstine

Abstract excerpt

AIMS: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in KV4.3 or in the auxiliary subunit K(+)...

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Source

Identifiers

PMID: 23400760
DOI: 10.1093/cvr/cvt028

Genes

KCND3
KCNIP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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