Article
Common and rare variants in SCN10A modulate the risk of atrial fibrillation.
Circulation. Cardiovascular genetics - 1 Feb 2015
Jabbari Javad, Olesen Morten S, Yuan Lei, Nielsen Jonas B, Liang Bo, Macri Vincenzo, Christophersen Ingrid E, Nielsen Nikolaj, Sajadieh Ahmad, Ellinor Patrick T, Grunnet Morten, Haunsø Stig, Holst Anders G, Svendsen Jesper H, Jespersen Thomas
Abstract excerpt
BACKGROUND: Genome-wide association studies have shown that the common single nucleotide polymorphism rs6800541 located in SCN10A, encoding the voltage-gated Nav1.8 sodium channel, is associated with PR-interval prolongation and atrial fibrillation (AF). Single nucleotide polymorphism rs6800541 is in high linkage disequilibrium with the nonsynonymous variant in SCN10A, rs6795970 (V1073A, r(2)=0.933). We therefore...
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