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Article

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.

Cardiovascular research - 1 Nov 2014

Savio-Galimberti Eleonora, Weeke Peter, Muhammad Raafia, Blair Marcia, Ansari Sami, Short Laura, Atack Thomas C, Kor Kaylen, Vanoye Carlos G, Olesen Morten Salling, LuCamp, Yang Tao, George Alfred L, Roden Dan M, Darbar Dawood

Abstract excerpt

AIMS: To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare coding sequence variation in the SCN10A gene, which encodes the voltage-gated sodium channel isoform NaV1.8 found primarily in peripheral nerves and to identify potentially disease-related mechanisms in high-priority rare variants using in-vitro electrophysiology. METHODS AND RESULTS: We re-sequenced SCN10A in 274...

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Identifiers

PMID: 25053638
DOI: 10.1093/cvr/cvu170
PMCID: PMC4271018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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