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Article

Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation.

Circulation - 15 Apr 2008

Darbar Dawood, Kannankeril Prince J, Donahue Brian S, Kucera Gayle, Stubblefield Tanya, Haines Jonathan L, George Alfred L, Roden Dan M

Abstract excerpt

BACKGROUND: Genetic studies have identified ion channel gene variants in families segregating atrial fibrillation (AF), the most common arrhythmia in clinical practice. Here, we tested the hypothesis that vulnerability to AF is associated with variation in SCN5A, the gene encoding the cardiac sodium channel. METHODS AND RESULTS: We resequenced the entire SCN5A coding region in 375 subjects with either lone AF...

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Identifiers

PMID: 18378609
DOI: 10.1161/CIRCULATIONAHA.107.757955
PMCID: PMC2365761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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