Article
Screening of KCNN3 in patients with early-onset lone atrial fibrillation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Jul 2011
Olesen Morten S, Jabbari Javad, Holst Anders G, Nielsen Jonas B, Steinbrüchel Daniel A, Jespersen Thomas, Haunsø Stig, Svendsen Jesper H
Abstract excerpt
AIMS: The aim of this study was to screen KCNN3 encoding the small-conductance calcium-activated K+ channel (SK3) in lone atrial fibrillation patients. Atrial fibrillation (AF) is the most common cardiac arrhythmia. A genome-wide association study has recently associated an intronic single-nucleotide polymorphism (SNP) in KCNN3 with lone AF. METHODS AND RESULTS: We sequenced the coding region and splice junctions...
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