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Article

IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation.

Journal of cardiovascular electrophysiology - 1 Jul 2015

Steffensen Annette Buur, Refsgaard Lena, Andersen Martin Nybo, Vallet Cecilia, Mujezinovic Amer, Haunsø Stig, Svendsen Jesper Hastrup, Olesen Søren-Peter, Olesen Morten Salling, Schmitt Nicole

Abstract excerpt

INTRODUCTION: Atrial fibrillation (AF) is the most frequent cardiac arrhythmia. The potassium current IKs is essential for cardiac repolarization. Gain-of-function mutation in KCNQ1, the gene encoding the pore-forming α-subunit of the IKs channel (KV 7.1), was the first ion channel dysfunction to be associated with familial AF. We hypothesized that early-onset lone AF is associated with a high prevalence of...

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Identifiers

PMID: 25786344
DOI: 10.1111/jce.12666

Genes

KCNQ1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation.PMID 25786344Read ↗

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