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Article

Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.

Circulation. Arrhythmia and electrophysiology - 1 Oct 2015

Hayashi Kenshi, Konno Tetsuo, Tada Hayato, Tani Satoyuki, Liu Li, Fujino Noboru, Nohara Atsushi, Hodatsu Akihiko, Tsuda Toyonobu, Tanaka Yoshihiro, Kawashiri Masa-aki, Ino Hidekazu, Makita Naomasa, Yamagishi Masakazu

Abstract excerpt

BACKGROUND: Few rare variants in atrial fibrillation (AF)-associated genes have been functionally characterized to identify a causal relationship between these variants and development of AF. We here sought to determine the clinical effect of rare variants in AF-associated genes in patients with lone AF and characterized these variants electrophysiologically and bioinformatically. METHODS AND RESULTS: We screened...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26129877
DOI: 10.1161/CIRCEP.114.002519

Genes

KCNA5
KCNH2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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