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Article

Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.

Human molecular genetics - 1 Nov 2009

Eijgelsheim Mark, Newton-Cheh Christopher, Aarnoudse Adrianus L H J, van Noord Charlotte, Witteman Jacqueline C M, Hofman Albert, Uitterlinden André G, Stricker Bruno H C

Abstract excerpt

Common variation within the nitric oxide-1 synthase activator protein (NOS1AP) locus is strongly related to QT interval, a sudden cardiac death (SCD) risk factor. A recent report describes common variation in NOS1AP associated with SCD in a US population of European ancestry. The objective of the current study was to obtain additional evidence by investigating the association between NOS1AP variants and SCD in...

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Share to Adaptor Proteins, Signal Transducing
Share to Death, Sudden, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Heart Rate

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Identifiers

PMID: 19643915
DOI: 10.1093/hmg/ddp356
PMCID: PMC2758139

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.PMID 19643915Read ↗

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population.Semantic proximity Read ↗

Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).Semantic proximity Read ↗

A common NOS1AP genetic polymorphism, rs12567209 G>A, is associated with sudden cardiac death in patients with chronic heart failure in the Chinese Han population.Semantic proximity Read ↗

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.Semantic proximity Read ↗

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.Semantic proximity Read ↗

NOS1AP Polymorphisms Modify QTc Interval Duration But Not Cardiac Arrest Risk in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.Semantic proximity Read ↗

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.Semantic proximity Read ↗

Association of common variants in NOS1AP gene with sudden unexplained nocturnal death syndrome in the southern Chinese Han population.Semantic proximity Read ↗

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