Article
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
Nature genetics - 1 Jun 2006
Arking Dan E, Pfeufer Arne, Post Wendy, Kao W H Linda, Newton-Cheh Christopher, Ikeda Morna, West Kristen, Kashuk Carl, Akyol Mahmut, Perz Siegfried, Jalilzadeh Shapour, Illig Thomas, Gieger Christian, Guo Chao-Yu, Larson Martin G, Wichmann H Erich, Marbán Eduardo, O'Donnell Christopher J, Hirschhorn Joel N, Kääb Stefan, Spooner Peter M, Meitinger Thomas, Chakravarti Aravinda
Abstract excerpt
Extremes of the electrocardiographic QT interval, a measure of cardiac repolarization, are associated with increased cardiovascular mortality. We identified a common genetic variant influencing this quantitative trait through a genome-wide association study on 200 subjects at the extremes of a population-based QT interval distribution of 3,966 subjects from the KORA cohort in Germany, with follow-up screening of...
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