Article
Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans.
Biological psychiatry - 1 Nov 2010
Dao David T, Mahon Pamela Belmonte, Cai Xiang, Kovacsics Colleen E, Blackwell Robert A, Arad Michal, Shi Jianxin, Zandi Peter P, O'Donnell Patricio, Knowles James A, Weissman Myrna M, Coryell William, Scheftner William A, Lawson William B, Levinson Douglas F, Thompson Scott M, Potash James B, Gould Todd D
Abstract excerpt
BACKGROUND: Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis. METHODS: The behaviors of wild-type and Cacna1c heterozygous mice of both sexes were evaluated in a number of tests. Based upon sex differences in our mouse data, we assessed a gene × sex interaction for diagnosis of mood disorders in...
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