Modeling madness in mice: one piece at a time.

Abstract excerpt

Mouse models that recapitulate the full phenotypic spectrum of a psychiatric disorder, such as schizophrenia, are impossible. However, a more piecemeal recreation of phenotypic components is feasible and promises to harness the power of animal models using approaches that are either off limits or confounded by drug treatment in humans. In that context, animal models will have a central and indispensable role in...

Topics

• Animals
• Disease Models, Animal
• Humans
• Mental Disorders
• Mice
• Mice, Transgenic
• Mutation