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Article

Detection of p53 dysfunction by flow cytometry in chronic lymphocytic leukaemia.

British journal of haematology - 1 Nov 2004

Carter A, Lin K, Sherrington P D, Pettitt A R

Abstract excerpt

In chronic lymphocytic leukaemia (CLL) cells, functional impairment of the p53 pathway is detectable by Western blotting as impaired up-regulation of p21 (a transcriptional target of p53) in response to ionizing radiation (IR). The type A defect is characterized by baseline p53 overexpression and is associated with TP53 mutation. The type B defect is characterized by impaired IR-induced p53 up-regulation and is...

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Share to Blotting, Western
Share to Cell Cycle Proteins
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, p53

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Tumor Suppressor Protein p53

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Source

Identifiers

PMID: 15521919
DOI: 10.1111/j.1365-2141.2004.05223.x

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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