Article
p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation.
Blood - 1 Aug 2001
Pettitt A R, Sherrington P D, Stewart G, Cawley J C, Taylor A M, Stankovic T
Abstract excerpt
The well-established association between TP53 mutations and adverse clinical outcome in a range of human cancers reflects the importance of p53 protein in regulating tumor-cell growth and survival. Although it is theoretically possible for p53 dysfunction to arise through mechanisms that do not i...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.