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Article

A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene.

Cancer research - 15 Jun 2009

Johnson Gillian G, Sherrington Paul D, Carter Anthony, Lin Ke, Liloglou Triantafillos, Field John K, Pettitt Andrew R

Abstract excerpt

The ATM-p53 pathway plays an important role in the biology of chronic lymphocytic leukemia (CLL). Its functional integrity can be probed by exposing CLL cells to ionizing radiation (IR) and measuring levels of p53 protein and one of its transcriptional targets, the cyclin-dependent kinase inhibitor p21. We have previously identified two abnormal p53/p21 response patterns associated with inactivating mutations of...

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Share to Base Sequence
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 19491257
DOI: 10.1158/0008-5472.CAN-09-0627

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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