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Article

DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing.

Blood - 3 Feb 2011

Mohr Julia, Helfrich Hanne, Fuge Maxi, Eldering Eric, Bühler Andreas, Winkler Dirk, Volden Matthias, Kater Arnon P, Mertens Daniel, Te Raa Doreen, Döhner Hartmut, Stilgenbauer Stephan, Zenz Thorsten

Abstract excerpt

The DNA damage pathway plays a central role in chemoresistance in chronic lymphocytic leukemia (CLL), as indicated by the prognostic impact of TP53 and ATM loss/mutations. We investigated the function of the p53 axis in primary CLL samples by studying p53 and p21 responses to irradiation by FACS...

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Share to Cell Adhesion
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Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 21115975
DOI: 10.1182/blood-2010-08-300160

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21115975-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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