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Targeting the p53 Pathway in CLL: State of the Art and Future Perspectives

18 Sept 2021

Abstract excerpt

The p53 pathway is a desirable therapeutic target, owing to its critical role in the maintenance of genome integrity. This is exemplified in chronic lymphocytic leukemia (CLL), one of the most common adult hematologic malignancies, in which functional loss of p53 arising from genomic aberrations are frequently associated with clonal evolution, disease progression, and therapeutic resistance, even in the...

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PMID: 34572908
DOI: 10.3390/cancers13184681

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