Article
Correlation between mutations in liaFSR of Enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints.
Antimicrobial agents and chemotherapy - 1 Aug 2012
Munita Jose M, Panesso Diana, Diaz Lorena, Tran Truc T, Reyes Jinnethe, Wanger Audrey, Murray Barbara E, Arias Cesar A
Abstract excerpt
Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a liaF mutation increased the DAP MIC of a vancomycin-resistant Enterococcus faecalis strain from 1 to 3 μg/ml (the DAP breakpoint is 4 μg/ml), suggesting that mutations in the liaFSR system could be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.