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Article

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.

Nucleic acids research - 19 May 2015

Davlieva Milya, Shi Yiwen, Leonard Paul G, Johnson Troy A, Zianni Michael R, Arias Cesar A, Ladbury John E, Shamoo Yousif

Abstract excerpt

LiaR is a 'master regulator' of the cell envelope stress response in enterococci and many other Gram-positive organisms. Mutations to liaR can lead to antibiotic resistance to a variety of antibiotics including the cyclic lipopeptide daptomycin. LiaR is phosphorylated in response to membrane stress to regulate downstream target operons. Using DNA footprinting of the regions upstream of the liaXYZ and liaFSR...

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Identifiers

PMID: 25897118
DOI: 10.1093/nar/gkv321
PMCID: PMC4482077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.PMID 25897118Read ↗

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