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Article

Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants.

Parkinsonism & related disorders - 1 Sept 2012

Wang Chaodong, Cai Yanning, Zheng Zheng, Tang Bei-Sha, Xu Yanming, Wang Tao, Ma Jinghong, Chen Sheng-Di, Langston J William, Tanner Caroline M, Chan Piu

Abstract excerpt

Variants in the LRRK2 gene are well-characterized genetic predisposing factors for PD worldwide, and LRRK2-associated PD is often indistinguishable from idiopathic PD (IPD). However, considerable heterogeneity of LRRK2-PD suggests the existence of additional genetic and/or environmental modifiers for LRRK2 carriers, which have yet to be confirmed by large-scale human studies. In a Chinese cohort consisting of...

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Identifiers

PMID: 22658533
DOI: 10.1016/j.parkreldis.2012.05.003

Genes

BST1
MAPT
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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