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Article

Exploring the Effects of Genetic Variants on Clinical Profiles of Parkinson's Disease Assessed by the Unified Parkinson's Disease Rating Scale and the Hoehn-Yahr Stage.

PloS one - 1 Jan 2016

Shi Chen, Zheng Zheng, Wang Qi, Wang Chaodong, Zhang Dabao, Zhang Min, Chan Piu, Wang Xiaomin

Abstract excerpt

Many genetic variants have been linked to familial or sporadic Parkinson's disease (PD), among which those identified in PARK16, BST1, SNCA, LRRK2, GBA and MAPT genes have been demonstrated to be the most common risk factors worldwide. Moreover, complex gene-gene and gene-environment interactions have been highlighted in PD pathogenesis. Compared to studies focusing on the predisposing effects of genes, there is...

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Source

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Identifiers

PMID: 27299523
DOI: 10.1371/journal.pone.0155758
PMCID: PMC4907455

Genes

BST1
MAPT
SNCA

Provenance

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