Article
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.
The Journal of cell biology - 7 Apr 2008
Van Damme Philip, Van Hoecke Annelies, Lambrechts Diether, Vanacker Peter, Bogaert Elke, van Swieten John, Carmeliet Peter, Van Den Bosch Ludo, Robberecht Wim
Abstract excerpt
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in PGRN were identified in patients with motor neuron degeneration, a condition that is related to FTLD. Most mutations identified in patients with FTLD until now have been null mutations. However, it remains unknown whether PGRN protein levels are...
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