Article
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.
Nature genetics - 27 May 2012
Fujimoto Akihiro, Totoki Yasushi, Abe Tetsuo, Boroevich Keith A, Hosoda Fumie, Nguyen Ha Hai, Aoki Masayuki, Hosono Naoya, Kubo Michiaki, Miya Fuyuki, Arai Yasuhito, Takahashi Hiroyuki, Shirakihara Takuya, Nagasaki Masao, Shibuya Tetsuo, Nakano Kaoru, Watanabe-Makino Kumiko, Tanaka Hiroko, Nakamura Hiromi, Kusuda Jun, Ojima Hidenori, Shimada Kazuaki, Okusaka Takuji, Ueno Masaki, Shigekawa Yoshinobu, Kawakami Yoshiiku, Arihiro Koji, Ohdan Hideki, Gotoh Kunihito, Ishikawa Osamu, Ariizumi Shun-Ichi, Yamamoto Masakazu, Yamada Terumasa, Chayama Kazuaki, Kosuge Tomoo, Yamaue Hiroki, Kamatani Naoyuki, Miyano Satoru, Nakagama Hitoshi, Nakamura Yusuke, Tsunoda Tatsuhiko, Shibata Tatsuhiro, Nakagawa Hidewaki
Abstract excerpt
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were associated with hepatitis B or C virus infections, including two sets of multicentric tumors. Although no common somatic mutations were identified in the multicentric tumor pairs, their whole-genome substitution patterns were similar, suggesting that...
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