Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers.

doi:10.1371/journal.pone.0114263

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Article

Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers.

PloS one - 1 Jan 2014

Shiraishi Yuichi, Fujimoto Akihiro, Furuta Mayuko, Tanaka Hiroko, Chiba Ken-ichi, Boroevich Keith A, Abe Tetsuo, Kawakami Yoshiiku, Ueno Masaki, Gotoh Kunihito, Ariizumi Shun-ichi, Shibuya Tetsuo, Nakano Kaoru, Sasaki Aya, Maejima Kazuhiro, Kitada Rina, Hayami Shinya, Shigekawa Yoshinobu, Marubashi Shigeru, Yamada Terumasa, Kubo Michiaki, Ishikawa Osamu, Aikata Hiroshi, Arihiro Koji, Ohdan Hideki, Yamamoto Masakazu, Yamaue Hiroki, Chayama Kazuaki, Tsunoda Tatsuhiko, Miyano Satoru, Nakagawa Hidewaki

Abstract excerpt

Recent studies applying high-throughput sequencing technologies have identified several recurrently mutated genes and pathways in multiple cancer genomes. However, transcriptional consequences from these genomic alterations in cancer genome remain unclear. In this study, we performed integrated and comparative analyses of whole genomes and transcriptomes of 22 hepatitis B virus (HBV)-related hepatocellular...

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Identifiers

PMID: 25526364
DOI: 10.1371/journal.pone.0114263
PMCID: PMC4272259

Genes

ARID2
AXIN1
CDK15
CPS1
TERT
THRAP3
TSC1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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