Article
Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity.
Nature communications - 30 Jan 2015
Fujimoto Akihiro, Furuta Mayuko, Shiraishi Yuichi, Gotoh Kunihito, Kawakami Yoshiiku, Arihiro Koji, Nakamura Toru, Ueno Masaki, Ariizumi Shun-ichi, Nguyen Ha Hai, Shigemizu Daichi, Abe Tetsuo, Boroevich Keith A, Nakano Kaoru, Sasaki Aya, Kitada Rina, Maejima Kazihiro, Yamamoto Yujiro, Tanaka Hiroko, Shibuya Tetsuo, Shibata Tatsuhiro, Ojima Hidenori, Shimada Kazuaki, Hayami Shinya, Shigekawa Yoshinobu, Aikata Hiroshi, Ohdan Hideki, Marubashi Shigeru, Yamada Terumasa, Kubo Michiaki, Hirano Satoshi, Ishikawa Osamu, Yamamoto Masakazu, Yamaue Hiroki, Chayama Kazuaki, Miyano Satoru, Tsunoda Tatsuhiko, Nakagawa Hidewaki
Abstract excerpt
Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show varying degrees of biliary epithelial differentiation, which can be defined as liver cancer displaying biliary phenotype (LCB). LCB is second in the incidence for liver cancers with and without chronic hepatitis background and more aggressive than hepatocellular carcinoma (HCC). To gain insight into its molecular alterations, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.