Article
High-resolution characterization of a hepatocellular carcinoma genome.
Nature genetics - 1 May 2011
Totoki Yasushi, Tatsuno Kenji, Yamamoto Shogo, Arai Yasuhito, Hosoda Fumie, Ishikawa Shumpei, Tsutsumi Shuichi, Sonoda Kohtaro, Totsuka Hirohiko, Shirakihara Takuya, Sakamoto Hiromi, Wang Linghua, Ojima Hidenori, Shimada Kazuaki, Kosuge Tomoo, Okusaka Takuji, Kato Kazuto, Kusuda Jun, Yoshida Teruhiko, Aburatani Hiroyuki, Shibata Tatsuhiro
Abstract excerpt
Hepatocellular carcinoma, one of the most common virus-associated cancers, is the third most frequent cause of cancer-related death worldwide. By massively parallel sequencing of a primary hepatitis C virus-positive hepatocellular carcinoma (36× coverage) and matched lymphocytes (>28× coverage) from the same individual, we identified more than 11,000 somatic substitutions of the tumor genome that showed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.