Article
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
Nature genetics - 1 May 2016
Fujimoto Akihiro, Furuta Mayuko, Totoki Yasushi, Tsunoda Tatsuhiko, Kato Mamoru, Shiraishi Yuichi, Tanaka Hiroko, Taniguchi Hiroaki, Kawakami Yoshiiku, Ueno Masaki, Gotoh Kunihito, Ariizumi Shun-Ichi, Wardell Christopher P, Hayami Shinya, Nakamura Toru, Aikata Hiroshi, Arihiro Koji, Boroevich Keith A, Abe Tetsuo, Nakano Kaoru, Maejima Kazuhiro, Sasaki-Oku Aya, Ohsawa Ayako, Shibuya Tetsuo, Nakamura Hiromi, Hama Natsuko, Hosoda Fumie, Arai Yasuhito, Ohashi Shoko, Urushidate Tomoko, Nagae Genta, Yamamoto Shogo, Ueda Hiroki, Tatsuno Kenji, Ojima Hidenori, Hiraoka Nobuyoshi, Okusaka Takuji, Kubo Michiaki, Marubashi Shigeru, Yamada Terumasa, Hirano Satoshi, Yamamoto Masakazu, Ohdan Hideki, Shimada Kazuaki, Ishikawa Osamu, Yamaue Hiroki, Chayama Kazuki, Miyano Satoru, Aburatani Hiroyuki, Shibata Tatsuhiro, Nakagawa Hidewaki
Abstract excerpt
Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-genome landscape of somatic alterations in 300 liver cancers from Japanese individuals. Our comprehensive analysis identified point mutations, structural variations (STVs), and virus integrations, in noncoding and coding regions. We...
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