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Article

Comprehensive genome sequencing of the liver cancer genome.

Cancer letters - 1 Nov 2013

Nakagawa Hidewaki, Shibata Tatsuhiro

Abstract excerpt

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Recently, comprehensive whole genome and exome sequencing analyses for HCC revealed new cancer-associated genes and a variety of genomic alterations. In particular, frequent genetic alterations of the chromatin remodeling genes were observed, suggesting a new potential therapeutic target for HCC. Sequencing analysis has...

Topics

Animals
Biomarkers, Tumor
Carcinoma, Hepatocellular
Chromatin Assembly and Disassembly
Computational Biology
DNA Mutational Analysis
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Genetic Testing
Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genomics

Hepatitis B virus

High-Throughput Nucleotide Sequencing

Humans

Liver Neoplasms

Mutation

Phenotype

Precision Medicine

Source

Identifiers

PMID: 23142287
DOI: 10.1016/j.canlet.2012.10.035

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