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Article

Molecular genomic landscapes of hepatobiliary cancer.

Cancer science - 1 May 2018

Shibata Tatsuhiro, Arai Yasuhito, Totoki Yasushi

Abstract excerpt

Hepatocellular carcinoma (HCC) and biliary tract cancer are more frequent in East Asia including Japan than in Europe or North America. A compilation of 1340 multi-ethnic HCC genomes, the largest cohort ever reported, identified a comprehensive landscape of HCC driver genes, comprised of three core drivers (TP53, TERT, and WNT signaling) and combinations of infrequent alterations in various cancer pathways. In...

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Share to Biliary Tract Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29573058
DOI: 10.1111/cas.13582
PMCID: PMC5980207

Genes

BAP1
IDH1
KRAS
SMAD4
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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