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Article

Diverse modes of genomic alteration in hepatocellular carcinoma.

Genome biology - 26 Aug 2014

Jhunjhunwala Suchit, Jiang Zhaoshi, Stawiski Eric W, Gnad Florian, Liu Jinfeng, Mayba Oleg, Du Pan, Diao Jingyu, Johnson Stephanie, Wong Kwong-Fai, Gao Zhibo, Li Yingrui, Wu Thomas D, Kapadia Sharookh B, Modrusan Zora, French Dorothy M, Luk John M, Seshagiri Somasekar, Zhang Zemin

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is a heterogeneous disease with high mortality rate. Recent genomic studies have identified TP53, AXIN1, and CTNNB1 as the most frequently mutated genes. Lower frequency mutations have been reported in ARID1A, ARID2 and JAK1. In addition, hepatitis B virus (HBV) integrations into the human genome have been associated with HCC. RESULTS: Here, we deep-sequence 42 HCC...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25159915
DOI: 10.1186/s13059-014-0436-9
PMCID: PMC4189592

Genes

CTNNB1
AXIN1
LAMA2
TERT
ARID2
BAP1
IDH1
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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