Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

doi:10.1038/ng.3126

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Article

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

Nature genetics - 1 Dec 2014

Totoki Yasushi, Tatsuno Kenji, Covington Kyle R, Ueda Hiroki, Creighton Chad J, Kato Mamoru, Tsuji Shingo, Donehower Lawrence A, Slagle Betty L, Nakamura Hiromi, Yamamoto Shogo, Shinbrot Eve, Hama Natsuko, Lehmkuhl Megan, Hosoda Fumie, Arai Yasuhito, Walker Kim, Dahdouli Mahmoud, Gotoh Kengo, Nagae Genta, Gingras Marie-Claude, Muzny Donna M, Ojima Hidenori, Shimada Kazuaki, Midorikawa Yutaka, Goss John A, Cotton Ronald, Hayashi Akimasa, Shibahara Junji, Ishikawa Shumpei, Guiteau Jacfranz, Tanaka Mariko, Urushidate Tomoko, Ohashi Shoko, Okada Naoko, Doddapaneni Harsha, Wang Min, Zhu Yiming, Dinh Huyen, Okusaka Takuji, Kokudo Norihiro, Kosuge Tomoo, Takayama Tadatoshi, Fukayama Masashi, Gibbs Richard A, Wheeler David A, Aburatani Hiroyuki, Shibata Tatsuhiro

Abstract excerpt

Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection of data from 503 liver cancer genomes from different populations uncovered 30 candidate driver genes and 11 core pathway...

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PMID: 25362482
DOI: 10.1038/ng.3126

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