Article
High-Resolution Genomic Profiling of Liver Cancer Links Etiology With Mutation and Epigenetic Signatures.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2023
Perez Shira, Lavi-Itzkovitz Anat, Gidoni Moriah, Domovitz Tom, Dabour Roba, Khurana Ishant, Davidovich Ateret, Tobar Ana, Livoff Alejandro, Solomonov Evgeny, Maman Yaakov, El-Osta Assam, Tsai Yishan, Yu Ming-Lung, Stemmer Salomon M, Haviv Izhak, Yaari Gur, Gal-Tanamy Meital
Abstract excerpt
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a model of a diverse spectrum of cancers because it is induced by well-known etiologies, mainly hepatitis C virus (HCV) and hepatitis B virus. Here, we aimed to identify HCV-specific mutational signatures and explored the link between the HCV-related regional variation in mutations rates and HCV-induced alterations in genome-wide chromatin organization....
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