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Article

Genomic landscape of hepatocarcinogenesis.

Journal of human genetics - 1 Sept 2021

Shibata Tatsuhiro

Abstract excerpt

Hepatocellular carcinoma (HCC) is a global health issue and the fourth leading cause of cancer deaths worldwide. Large-scale HCC genome sequencing analyses have identified core drivers (TERT, TP53, and CTNNB1/AXIN1) as initial molecular events, and other low-frequent drivers that include therapeutically targetable ones. The recent genetic analysis uncovered a distinctive driver gene landscape in precancerous...

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Carcinogenesis
Carcinoma, Hepatocellular
Cohort Studies
Genome, Viral
Genomics
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

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PMID: 33958712
DOI: 10.1038/s10038-021-00928-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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