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Article

Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis.

Journal of lipid research - 1 Aug 2012

Wang Chen-Yu, Stapleton Donald S, Schueler Kathryn L, Rabaglia Mary E, Oler Angie T, Keller Mark P, Kendziorski Christina M, Broman Karl W, Yandell Brian S, Schadt Eric E, Attie Alan D

Abstract excerpt

Nonalchoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction and is associated with metabolic diseases, including obesity, insulin resistance, and type 2 diabetes. We mapped a quantitative trait locus (QTL) for NAFLD to chromosome 17 in a cross between C57BL/6 (B6) and BTBR mouse strains made genetically obese with the Lep(ob/ob) mutation. We identified Tsc2 as a gene underlying the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22628617
DOI: 10.1194/jlr.M025239
PMCID: PMC3540861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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