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Article

TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.

Journal of molecular endocrinology - 1 Apr 2014

Ishizuka Yuumi, Nakayama Kazuhiro, Ogawa Ayumi, Makishima Saho, Boonvisut Supichaya, Hirao Atsushi, Iwasaki Yusaku, Yada Toshihiko, Yanagisawa Yoshiko, Miyashita Hiroshi, Takahashi Masafumi, Iwamoto Sadahiko

Abstract excerpt

Mammalian tribbles homolog 1 (TRIB1) regulates hepatic lipogenesis and is genetically associated with plasma triglyceride (TG) levels and cholesterol, but the molecular mechanisms remain obscure. We explored these mechanisms in mouse livers transfected with a TRIB1 overexpression, a shRNA template or a control (LacZ) adenovirus vector. The overexpression of TRIB1 reduced, whereas induction of the shRNA template...

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Source

Identifiers

PMID: 24389359
DOI: 10.1530/JME-13-0243

Genes

TRIB1
MLXIPL
MAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.PMID 24389359Read ↗

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