Article

Modelling Porcine NAFLD by Deletion of Leptin and defining the role of AMPK in hepatic fibrosis

2021-06-07

Abstract excerpt

Liver fibrosis occurs during chronic liver disease. Advanced liver fibrosis results in cirrhosis, liver failure and often requires liver transplantation. However, due to the lack of human models, mechanisms underlining the pathogenesis of liver fibrosis remain unclear. Recent studies implicated a central role of deranged lipid metabolism in its pathogenesis. In this study, we generated LEPTIN-deficient ( LEPTIN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 239ebb7a-c9dc-5eb3-b9b5-e4b4d6ba5a52
DOI: 10.1101/2021.06.07.447327

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modelling Porcine NAFLD by Deletion of Leptin and defining the role of AMPK in hepatic fibrosisDOI 10.1101/2021.06.07.447327Read

Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis.Semantic proximity Read

Mouse models in non‐alcoholic fatty liver disease and steatohepatitis researchSemantic proximity Read

Animal models of NASH: getting both pathology and metabolic context right.Semantic proximity Read

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma.Semantic proximity Read

A systematic analysis of rodent models implicates adipogenesis and innate immunity in pathogenesis of fatty liver diseaseSemantic proximity Read

Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances.Semantic proximity Read

Adipocyte JAK2 mediates aging-associated metabolic liver disease and progression to hepatocellular carcinomaSemantic proximity Read

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner.Semantic proximity Read

Non-alcoholic steatohepatitis: what can we learn from animal models?Semantic proximity Read

Hepatic stellate cells-specific Loxl1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH miceSemantic proximity Read

Experimental Models to Investigate PNPLA3 in Liver Steatosis.Semantic proximity Read

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice.Semantic proximity Read