Article
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.
Scientific reports - 27 Feb 2017
Grünberg John R, Hoffmann Jenny M, Hedjazifar Shahram, Nerstedt Annika, Jenndahl Lachmi, Elvin Johannes, Castellot John, Wei Lan, Movérare-Skrtic Sofia, Ohlsson Claes, Holm Louise Mannerås, Bäckhed Fredrik, Syed Ismail, Bosch Fatima, Saghatelian Alan, Kahn Barbara B, Hammarstedt Ann, Smith Ulf
Abstract excerpt
WISP2 is a novel adipokine, most highly expressed in the adipose tissue and primarily in undifferentiated mesenchymal cells. As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as an intracellular protein, it helps to maintain precursor cells undifferentiated. To examine effects of increased WISP2 in vivo, we generated an aP2-WISP2 transgenic (Tg) mouse. These mice had...
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