Article
Type 2 diabetes mouse model TallyHo carries an obesity gene on chromosome 6 that exaggerates dietary obesity.
Physiological genomics - 14 Jul 2005
Kim Jung Han, Stewart Taryn P, Zhang Weidong, Kim Hyoung Yon, Nishina Patsy M, Naggert Jürgen K
Abstract excerpt
The TallyHo (TH) mouse strain is a polygenic model for Type 2 diabetes with obesity. Genetic analysis in backcross progeny from a cross between F1 [C57BL/6J (B6) x TH] and TH mice mapped a quantitative trait locus (QTL) named TH-associated body weight 2 (tabw2) to chromosome 6. The TH-derived allele is associated with increased body weight. As a first step to identify the molecular basis of this obesity QTL, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.