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Article

Tachol1 QTL on mouse chromosome 1 is responsible for hypercholesterolemia and diet-induced obesity.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2024

Kim Jung Han, Simpkins Marvin A, Williams Nicholas T, Cimino Emma, Simon Jadyn, Richmond Tanner R, Youther Jared, Slutz Hannah, Denvir James

Abstract excerpt

Hypercholesterolemia raises the risk for cardiovascular complications and overall health. Hypercholesterolemia is common, affecting 10% of the general population of the US, and heritable. Most individuals with hypercholesterolemia have a polygenic predisposition to the condition. Previously we identified a quantitative trait locus, Tachol1, linked to hypercholesterolemia on mouse chromosome 1 (Chr1) in a cross...

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Share to Chromosomes, Mammalian
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Congenic

Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 38837040
DOI: 10.1007/s00335-024-10045-4
PMCID: PMC11339885

Genes

TH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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