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Article

Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008

Rachdi Latif, Balcazar Norman, Osorio-Duque Fernando, Elghazi Lynda, Weiss Aaron, Gould Aaron, Chang-Chen Karen J, Gambello Michael J, Bernal-Mizrachi Ernesto

Abstract excerpt

Regulation of pancreatic beta cell mass and function is a major determinant for the development of diabetes. Growth factors and nutrients are important regulators of beta cell mass and function. The signaling pathways by which these growth signals modulate these processes have not been completely elucidated. Tsc2 is an attractive candidate to modulate these processes, because it is a converging point for growth...

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Identifiers

PMID: 18587048
DOI: 10.1073/pnas.0803047105
PMCID: PMC2453727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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