Article
Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice.
Development (Cambridge, England) - 1 Jul 2012
Hoshi Masato, Batourina Ekatherina, Mendelsohn Cathy, Jain Sanjay
Abstract excerpt
Mutations in the receptor tyrosine kinase RET are associated with congenital anomalies of kidneys or urinary tract (CAKUT). RET tyrosine Y1015 is the docking site for PLCγ, a major regulator of RET signaling. Abrogating signaling via Y1015 causes CAKUT that are markedly different than renal agenesis in Ret-null or RetY1062F mutant mice. We performed analysis of Y1015F mutant upper and lower urinary tracts in mice...
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