Article
The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development
13 May 2010
Abstract excerpt
Signaling by the Ret receptor tyrosine kinase promotes cell movements in the Wolffian duct that give rise to the first ureteric bud tip, initiating kidney development. Although the ETS transcription factors Etv4 and Etv5 are known to be required for mouse kidney development and to act downstream of Ret, their specific functions are unclear. Here, we examine their role by analyzing the ability of Etv4 Etv5...
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