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Article

Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion.

Journal of the American Society of Nephrology : JASN - 1 Mar 2018

Hoshi Masato, Reginensi Antoine, Joens Matthew S, Fitzpatrick James A J, McNeill Helen, Jain Sanjay

Abstract excerpt

The epithelial Wolffian duct (WD) inserts into the cloaca (primitive bladder) before metanephric kidney development, thereby establishing the initial plumbing for eventual joining of the ureters and bladder. Defects in this process cause common anomalies in the spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). However, developmental, cellular, and molecular mechanisms of WD-cloaca fusion...

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PMID: 29326158
DOI: 10.1681/ASN.2017040380
PMCID: PMC5827592

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