Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a<i>Gata3-Raldh2-Ret</i>molecular network in mice

Abstract excerpt

Urinary tract development depends on a complex series of events in which the ureter moves from its initial branch point on the nephric duct (ND) to its final insertion site in the cloaca (the primitive bladder and urethra). Defects in this maturation process can result in malpositioned ureters and hydronephrosis, a common cause of renal disease in children. Here, we report that insertion of the ND into the cloaca...

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