Article
Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.
Development (Cambridge, England) - 1 Jun 1996
Schuchardt A, D'Agati V, Pachnis V, Costantini F
Abstract excerpt
The c-ret gene encodes a receptor tyrosine kinase that is expressed in the Wolffian duct and ureteric bud of the developing excretory system. Newborn mice homozygous for a mutation in c-ret displayed renal agenesis or severe hypodysplasia, suggesting a critical role for this gene in metanephric kidney development. To investigate the embryological basis of these defects, we characterized the early development of...
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